Retatrutide is a Triple–Hormone-Receptor Agonist.

Retatrutide is an investigational single molecule that activates the body’s receptors for three hormones – glucagon, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1), and is being studied for the treatment of obesity. Retatrutide is an acylated peptide suitable for weekly injection.