MOTS-C is a mitochondrial-derived peptide (MDP) consisting of 16 amino acids. MDPs are bioactive hormones that have significant effects on energy regulation, skeletal muscle function, and mitochondrial communication.

MOTS-C has garnered attention in recent years due to its therapeutic potential in various processes, including weight regulation, metabolism, longevity, exercise capacity, skeletal muscle growth, and disease-related pathways.